Resveratrol Does Damage Control

Resveratrol is one of the hottest up and coming antioxidants. Resveratrol is a polyphenol that is most notably found in grapes and red wine. For a long time many people believe that red wine was a superior type of alcohol because of its high resveratrol content. Recently I co-authored a scientific manuscript in which we found that resveratrol has little to nothing to do with the increase in "good" cholesterol found with moderate red wine (or any alcohol for that matter) consumption.

Regardless of resveratrol's lack of influence on HDL cholesterol it has been shown to have powerful anti-aging and anti-inflammatory effects in animal and in vitro studies. This is where I see the main problem with Resveratrol research to date. There is a complete lack of direct human data. The amounts of resveratrol being given to mice and rats in the animal studies far exceeds the amounts one can consume by drinking red wine. Resveratrol supplements are now becoming more popular and those dosages are more comparable to the ones used in animal studies.

Most recently I came across a new study from the Journal of Applied Physiology in which researchers found that when human endothelial cells were exposed to oxidized LDL cholesterol (oxLDL) particles (these are thought to be one of the molecules that begins the cascade of events leading to heart disease) in the presence of resveratrol. The oxLDL had a decreased ablilty to cause the generation of reactive oxygen species. Reactive oxygen species are molecules turned rouge that fly around our system causing cellular and DNA damage until are quenched by anti-oxidants. From this research is seems that resveratol can protect against oxidative damage by

1. Quenching reactive oxygen species
2. Slowing down the cellular machinery that produces reactive oxygen species

This is just another feather in the cap of resveratrol and with data like this being produced every month you can bet that resveratrol will have a central role in the prevention and treatment of many diseases in the future.

Tags: resveratrol, heart disease, antioxidants, DNA damage